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cb1r inverse agonist am251  (Tocris)


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    Structured Review

    Tocris cb1r inverse agonist am251
    Cb1r Inverse Agonist Am251, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1359 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cb1r+inverse+agonist+am251/AM+251/pm41439716-339-20-29
    Average 96 stars, based on 1359 article reviews
    cb1r inverse agonist am251 - by Bioz Stars, 2026-10
    96/100 stars

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    Related Articles

    Injection:

    Article Title: Cannabinoid receptor type 1 antagonists alter aspects of risk/reward decision making independent of toluene-mediated effects
    Article Snippet: .. Systemic drug administration and inhalation chamber treatments In some studies, rats received an intra-peritoneal (i.p.) injection of the CB1R inverse agonist AM251 (2 mg/kg; Tocris Bioscience) or vehicle (DMSO) 15 min prior to gas exposures in a 30×30×30 cm inhalation chamber ( , Plas Labs, Lansing, MI). ..

    Article Title: Cannabinoid receptor type 1 antagonists alter aspects of risk/reward decision making independent of toluene-mediated effects.
    Article Snippet: Drugs of abuse including cannabis and inhalants impair risk/reward decision making.. Cannabis use is often concurrent with inhalant intoxication; yet, preclinical studies investigating the role of endocannabinoids in inhalant misuse are limited.. To address this gap in the literature, we used the well-validated probabilistic discounting task to assess risk/reward decision making in rodents following combinations of toluene vapor (a common inhalant) and manipulations of cannabinoid receptor type 1 (CB1R) signaling.

    Article Title: Cannabinoid receptor type 1 antagonists alter aspects of risk/reward decision making independent of toluene-mediated effects
    Article Snippet: .. In some studies, rats received an intra-peritoneal (i.p.) injection of the CB1R inverse agonist AM251 (2 mg/kg; Tocris Bioscience) or vehicle (DMSO) 15 min prior to gas exposures in a 30×30×30 cm inhalation chamber ( , Plas Labs, Lansing, MI). ..

    other:

    Article Title: The Blue Light‐Responsive Lateral Pathway of the Retinohypothalamic Tract Promotes Endocannabinoid‐Driven Modulation of Orexin Neurons
    Article Snippet: In a subset of experiments, the CB1R inverse agonist AM251 (Tocris cat no. 1117, 1 mg/kg) was administered intraperitoneally (i.p.) 1 h before the start of the recording session.

    Article Title: The Blue Light-Responsive Lateral Pathway of the Retinohypothalamic Tract Promotes Endocannabinoid-Driven Modulation of Orexin Neurons.
    Article Snippet: In a subset of experiments, the CB1R inverse agonist AM251 (Tocris cat no. 1117, 1 mg/kg) was administered intraperitoneally (i.p.) 1 h before the start of the recording session.

    Saline:

    Article Title: Cannabis produces acute hyperphagia in humans and rodents via increased reward valuation for, and motivation to, acquire food.
    Article Snippet: .. 30 min prior to vapor exposure, rats were subjected to IP injections of vehicle (5% DMSO, 5% tween, 90% saline), CB1R inverse agonist AM251 (1 mg/kg in vehicle; #1117, Tocris Bioscience, Bristol, UK), peripherally restricted CB1R antagonist AM6545 (2 mg/kg in vehicle, provided by K. Vemuri and A. Makriyanis, Northeastern University, Boston, MA, USA), or peripherally restricted CB1R inverse agonist JD5037 (3 mg/kg in vehicle, #1HY- 18697, Cedarlane, Burlington, Ontario, Canada). ..



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    Fig. 1. Molecular and functional evidence of the presence of the <t>CB1R</t> in the intramural coronary
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    Fig. 1. Molecular and functional evidence of the presence of the <t>CB1R</t> in the intramural coronary
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    Fig. 1. Molecular and functional evidence of the presence of the CB1R in the intramural coronary

    Journal: Prostaglandins & other lipid mediators

    Article Title: Control of myogenic tone and agonist induced contraction of intramural coronary resistance arterioles by cannabinoid type 1 receptors and endocannabinoids.

    doi: 10.1016/j.prostaglandins.2017.10.001

    Figure Lengend Snippet: Fig. 1. Molecular and functional evidence of the presence of the CB1R in the intramural coronary

    Article Snippet: The neutral CB1R antagonist O2050, the inverse CB1R agonist AM251 were purchased from Tocris Bioscience (Elliswille, MI, US).

    Techniques: Functional Assay